Season 2 (12 episodes)

1. Season 2 - Episode 1 Corn Snake

2. Season 2 - Episode 2 Cooking with Jesus

3. Season 2 - Episode 3 Last Tango in Agrestic

4. Season 2 - Episode 4 A.K.A The Plant

5. Season 2 - Episode 5 Mrs. Botwin's Neighborhood

6. Season 2 - Episode 6 Crush Girl Love Panic

7. Season 2 - Episode 7 Must Find Toes

8. Season 2 - Episode 8 MILF Money

9. Season 2 - Episode 9 Bash

10.Season 2 - Episode 10 Mile Deep and a Foot Wide

11.Season 2 - Episode 11 Yeah, Just Like Tomatoes

12.Season 2 - Episode 12 Pittsburgh

The second season, while still comedic, has a much darker tone, as Nancy becomes increasingly involved in the more dangerous aspects of the drug "underground". Ignoring Heylia's advice, Nancy and Conrad start their own small-scale growing operation and eventually rent a suburban grow-house. She welcomes other people into her business, including her brother-in-law Andy and Doug. During this season, Peter Scottson tells Nancy he knows she is a drug dealer, but considers her too small time to be worth busting, and the two are married as part of a deal to legally protect Nancy from Peter testifying in a court of law. While Nancy's drug activities increase, Celia runs for, and wins, Doug's spot on the town council: she launches a drug-free campaign across Agrestic complete with drug-free zone signs and surveillance cameras. Doug has a brief sexual affair with Celia.

Silas and Megan's relationship threatens to split apart once she leaves for college; he attempts to get her pregnant to circumvent this, but his success leads to an abortion and a violent confrontation with Megan's father, ending the relationship. Andy tries to develop a relationship with an attractive, sexually formidable instructor, Yael Hoffman, at his rabbinical school, which falls apart once he drops out due to an incident where a dog bites off two of his small toes, which he thinks will clear him from military duty.

As the season progresses, Nancy's children become more aware of her illegal activities, though the two sons deal with the issue in quite different ways. Shane continues to have problems fitting in at school, but ends up joining the debate team in order to get closer to Gretchen, who later ends up becoming Shane's girlfriend. Despite Shane's apparent interest in Gretchen, he breaks up with her because of his extreme interest in Andy's crazy ex-girlfriend, Kat. Silas, on the other hand, takes out his frustrations by committing acts of vandalism, most notably stealing Celia's drug-free zone signs and cameras.

Nancy and Conrad's drug business becomes a hit as Conrad's strain of plant (which Snoop Dogg dubs "MILFweed" during a happenstance meeting at a recording studio) pleases their customers; but their high profile causes trouble. Initially, Nancy's marriage to a DEA agent keeps her on top while her Armenian rivals are busted, but her marriage to Peter deteriorates as he pressures her to quit dealing. For Nancy, the final straw is when Peter comes over for dinner and manhandles Silas. Nancy calls Conrad and tells him that she doesn't love Peter but will string him along until the current harvest is done; Peter hears the conversation with wireless surveillance.

The season concludes with a complex series of betrayals, as Peter demands of Nancy and Conrad all of the cash from a quick sale of their crop. Secretly, Heylia hires Armenian mobsters to kill Peter in retaliation. Nancy's buyer, U-Turn, demands the entire crop of weed at gunpoint. Having just killed Peter, the Armenian mobsters arrive at the same time and expect the proceeds from the big sale to pay for their hit, but finding that U-Turn had decided to jack the weed and that there is no money, decide they will take the weed instead. Only then does Nancy discover that Silas has decided to force his way into the business by stealing the entire batch of weed and demanding to be part of the business. After hiding the batch in his car trunk, he is approached by Celia and a police officer for the theft of the drug-free zone signs and surveillance cameras, as Celia has footage of Silas stealing the last camera. This leaves Nancy at the grow house, in a Mexican standoff with both the gangsters and the mobsters pointing guns at her in a season-ending cliffhanger..