Won

Satellite Awards Outstanding Actress in a Series- Comedy Mary-Louise Parker 2005

Golden Globe Awards Best Performance by a TV Actress in a Musical or Comedy Mary-Louise Parker 2006

Satellite Awards Outstanding Actor in a Series- Comedy Justin Kirk 2008


Nominated
Golden Globe Awards
Best TV Series-Comedy (2006, 2007, 2009)

Best Performance by a TV Supporting Actress Elizabeth Perkins (2006, 2007)

Best Performance by a TV Actress in a Musical or Comedy Mary-Louise Parker (2007, 2008, 2009)

Best Performance by a TV Supporting Actor Justin Kirk (2007)
Screen Actors Guild

Outstanding Performance by a Female Actor in a Comedy Series Mary-Louise Parker (2006, 2007, 2008, 2009)

Ensemble In A Comedy Series (2007, 2009)

Satellite Awards
Outstanding Actress in a Series-Comedy Elizabeth Perkins (2005)

Best Actress in a Supporting Role in a Series, Mini-series, or TV Movie Elizabeth Perkins(2006)

Best Actress in a Series, Comedy or Musical Mary-Louise Parker (2006, 2008)

Best Actor in a Supporting Role in a Series, Mini-Series, or TV Movie Justin Kirk (2007)

Best Television Series, Comedy or Musical (2007, 2008)
Emmy Awards

Outstanding Supporting Actress in a Comedy Series Elizabeth Perkins (2006, 2007, 2009)

Outstanding Directing for a Comedy Series Craig Zisk, for the episode Good Shit Lollipop (2006)

Outstanding Casting for a Comedy Series (2006, 2007)

Outstanding Main Title Design (2006)

Outstanding Single-Camera Picture Editing for a Comedy Series, for the episode Good Shit Lollipop (2006)

Outstanding Lead Actress in a Comedy Series Mary-Louise Parker (2007, 2008, 2009)

Outstanding Single-Camera Picture Editing for a Comedy Series, for the episode Mrs. Botwin's Neighborhood (2007)

Outstanding Single-Camera Picture Editing for a Comedy Series, for the episode Crush Girl Love Panic (2007)

Outstanding Comedy Series (2009)